Until now, a significant barrier to integration has been the absence of a functioning vascular system.
Karande previously made two types of living human cells into “bio-inks,” and print them into a skin-like structure. He now includes human endothelial cells, which line the inside of blood vessels, and human pericyte cells, which wrap around the endothelial cells — with animal collagen and other structural cells typically found in a skin graft.
The cells start communicating and forming a biologically relevant vascular structure within the span of a few weeks.
Karande said more work will need to be done to address the challenges associated with burn patients, which include the loss of nerve and vascular endings. But the grafts his team has created bring researchers closer to helping people with more discrete issues, like diabetic or pressure ulcers.
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