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Artificial spleen-on-a-chip to treat sepsis

http://wyss.harvard.edu/viewpressrelease/108/

Harvard researchers are developing a device that could be used to rapidly remove pathogens from the blood of patients with sepsis.  The dialysis-like machine acts as an artificial spleen, filtering the blood using injectable magnetic nanobeads engineered to stick to microorganisms and toxins.  After the beads are injected, blood is removed and run through a device that uses a magnetic-field gradient to extract the nanobead-bound germs. The blood is then returned to the body.  The team at the Wyss Institute for Biologically Inspired Engineering hopes that the device will be able to identify the specific microorganism causing the patient’s blood infection.  This could help physicians more quickly determine the most effective antibiotic treatment.

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